The AMES-Test, a bacterial reverse mutation test, is a tool to determine the mutagenic effect of substances, for example in pharmaceutical research or in the risk assessment of chemical substances. The method is based on bacteria which are no longer able to synthesise essential amino acids. These bacteria are incubated with potential mutagens on a substrate preventing reproduction. If new bacterial colonies occur, it is demonstrated that they have regained the capacity for synthesis.
Labor LS performs AMES-Tests for its customers and also generates all documentation required by the authorities for approval, permission, registration or notification procedures. The tests are conducted according to the requirements of Good Laboratory Practice (GLP).
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