Monocyte activation test

The monocyte activation test (MAT) was included in the European Pharmacopoeia (Ph. Eur. 2.6.30) in 2010. The MAT is an in-vitro test based on the human fever reaction with human whole blood or human blood cells (monocytes). It combines the advantages of the rabbit test and the LAL test without their specific disadvantages. The results can be transferred directly to humans as the MAT reacts species-specifically on the basis of human monocytes and does not need to be transferred to another biological system.

Labor LS offers the monocyte activation test as an important supplement to the LAL tests, as it not only detects endotoxins exclusively and at the same time offers similarly high sensitivity. However, a product-specific development and validation is a prerequisite for the application of the test.